Prokolagen-prolin 3-dioksigenaza
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| Prokolagen-prolin 3-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.7 | ||||||||
| CAS broj | 63551-75-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prokolagen-prolin 3-dioksigenaza (EC 1.14.11.7, prolin,2-oksoglutaratna 3-dioksigenaza, prolilna 3-hidroksilaza, protokolagen prolinska 3-hidroksilaza, prolil-4-hidroksiprolil-glicil-peptid, 2-oksoglutarat: kiseonik oksidoreduktaza, 3-hidroksilacija) je enzim sa sistematskim imenom prokolagen-L-prolin,2-oksoglutarat:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- prokolagen L-prolin + 2-oksoglutarat + O2 prokolagen trans-3-hidroksi-L-prolin + sukcinat + CO2
Za rad ovog enzima se neophodni Fe2+ i askorbat.
Reference[uredi | uredi kod]
- ↑ Risteli, J., Tryggvason, K. and Kivirikko, K.I. (1977). „Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex”. Eur. J. Biochem. 73: 485-492. PMID 191255.
- ↑ Risteli, J., Tryggvason, K. and Kivirikko, K.I. (1978). „A rapid assay for prolyl 3-hydroxylase activity”. Anal. Biochem. 84: 423-431. PMID 204218.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.