Prenilcistein oksidaza
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| Prenilcistein oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.3.5 | ||||||||
| CAS broj | 196717-99-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prenilcistein oksidaza (EC 1.8.3.5, prenilcisteinska lijaza) je enzim sa sistematskim imenom S-prenil-L-cistein:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-prenil-L-cistein + O2 +H2O prenal + L-cistein +H2O2
Ovaj enzim je flavoprotein (FAD). On raskida tioetarsku vezu S-prenil-L-cisteina, kao što je S-farnezilcistein i S-geranilgeranilcistein.
Reference[uredi | uredi kod]
- ↑ Zhang, L., Tschantz, W.R. and Casey, P.J. (1997). „Isolation and characterization of a prenylcysteine lyase from bovine brain”. J. Biol. Chem. 272: 23354-23359. PMID 9287348.
- ↑ Tschantz, W.R., Digits, J.A., Pyun, H.J., Coates, R.M. and Casey, P.J. (2001). „Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase”. J. Biol. Chem. 276: 2321-2324. PMID 11078725.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.