Pitrilizin

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Pitrilizin
Identifikatori
EC broj 3.4.24.55
CAS broj 81611-78-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Pitrilizin (EC 3.4.24.55, Escherichia coli proteaza III, proteaza Pi, proteinaza Pi, PTR, Escherichia coli metaloproteinaza Pi) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno razlaganje -Tyr16-Leu- i -Phe25-Tyr- veza oksidovanog lanca insulina B. Takođe deluje na druge supstrate sa masom manjom od 7 kDa, kao što su insulin i glukagon

Ovaj enzim je prisutan u bakteriji Escherichia coli.

Reference[uredi | uredi kod]

  1. Finch, P.W., Wilson, R.E., Brown, K., Hickson, I.D. and Emmerson, P.T. (1986). „Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III”. Nucleic Acids Res. 14: 7695-7703. PMID 3534791. 
  2. Affholter, J.A., Fried, V.A. and Roth, R.A. (1988). „Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III”. Science 242: 1415-1418. PMID 3059494. 
  3. Becker, A.B. and Roth, R.A. (1992). „An unusual active site identified in a family of zinc metalloendopeptidases”. Proc. Natl. Acad. Sci. USA 89: 3835-3839. PMID 1570301. 
  4. Ding, L., Becker, A.B., Suzuki, A. and Roth, R.A. (1992). „Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III”. J. Biol. Chem. 267: 2414-2420. PMID 1733942. 
  5. Anastasi, A., Knight, C.G. and Barrett, A.J. (1993). „Characterization of the bacterial metalloendopeptidase pitrilysin by use of a continuous fluorescence assay”. Biochem. J. 290: 601-607. PMID 7680857. 

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