Piroglutamilna peptidaza II
(Preusmjereno sa stranice Piroglutamil-peptidaza II)
| Piroglutamilna peptidaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.6 | ||||||||
| CAS broj | 60063-88-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Piroglutamilna peptidaza II (EC 3.4.19.6, tiroliberinaza, piroglutamilna aminopeptidaza II, , tirotropin-oslobađajući faktor piroglutamatna aminopeptidaza, piroglutamatna aminopeptidaza II, tiroliberin-hidrolizujuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća piroglutamatna aminopeptidaza, tirotropin-oslobađajuća hormon-degradirajuća peptidaza, TRH aminopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalne piroglutamilne grupe sa pGlu-His-Xaa tripeptida i pGlu-His-Xaa-Gly tetrapeptida
Ovaj enzim je visoko specifičan za tireotropin oslobađajući hormon.
Reference[uredi | uredi kod]
- ↑ Bauer, K. and Nowak, P. (1979). „Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond”. Eur. J. Biochem. 99: 239-246. PMID 115687.
- ↑ O'Connor, B. and O'Cuinn, G. (1985). „Purification of and kinetic studies on a narrow specifity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain”. Eur. J. Biochem. 150: 47-52. PMID 2862039.
- ↑ Wilk, S. and Wilk, E.K. (1989). „Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme”. Neurochem. Int. 15: 81-89.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.