Pirimidin-nukleozid fosforilaza
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| Pirimidin-nukleozid fosforilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.2 | ||||||||
| CAS broj | 9055-35-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pirimidin-nukleozid fosforilaza (EC 2.4.2.2, Py-NPase) je enzim sa sistematskim imenom pirimidin-nukleozid:fosfat alfa-D-riboziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- pirimidin nukleozid + fosfat pirimidinska baza + alfa-D-riboza 1-fosfat
Uridin i timidin su supstrati.
Reference[uredi | uredi kod]
- ↑ Friedkin, M. and Kalckar, H. (1961). „Nucleoside phosphorylases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 237-255.
- ↑ Saunders, P.P., Wilson, B.A. and Saunders, G.F. (1969). „Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus”. J. Biol. Chem. 244: 3691-3697. PMID 4978445.
- ↑ Hamamoto, T., Noguchi, T. and Midorikawa, Y. (1996). „Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2”. Biosci. Biotechnol. Biochem. 60: 1179-1180. PMID 8782414.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Friedkin, M. and Kalckar, H. (1961). „Nucleoside phosphorylases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 5 (2nd izd.). New York: Academic Press. str. 237-255.