Piridoksin 5'-fosfat sintaza
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| Piridoksin 5'-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.99.2 | ||||||||
| CAS broj | 230310-47-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Piridoksin 5'-fosfat sintaza (EC 2.6.99.2, piridoksin 5-fosfat fosfo lijaza, PNP sintaza, PdxJ) je enzim sa sistematskim imenom 1-dezoksi-D-ksiluloza-5-fosfat:3-amino-2-oksopropil fosfat 3-amino-2-oksopropiltransferaza (fosfat-hidroliza; ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-dezoksi-D-ksiluloza 5-fosfat + 3-amino-2-oksopropil fosfat piridoksin 5'-fosfat + fosfat + 2H2O
Kod Escherichia coli, koenzim piridoksal 5'-fosfat se sintetizuje de novo.
Reference[uredi | uredi kod]
- ↑ Garrido-Franco, M. (2003). „Pyridoxine 5′-phosphate synthase: de novo synthesis of vitamin B6 and beyond”. Biochim. Biophys. Acta 1647: 92-97. PMID 12686115.
- ↑ Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. (2002). „Enzyme-ligand complexes of pyridoxine 5′-phosphate synthase: implications for substrate binding and catalysis”. J. Mol. Biol. 321: 601-612. PMID 12206776.
- ↑ Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B6 biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45-48. PMID 10225425.
- ↑ Franco, M.G., Laber, B., Huber, R. and Clausen, T. (2001). „Structural basis for the function of pyridoxine 5′-phosphate synthase”. Structure 9: 245-253. PMID 11286891.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.