Pimelil-(acil-nosilac protein) metil estarska esteraza

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Pimelil-(acil-nosilac protein) metil estarska esteraza
Identifikatori
EC broj 3.1.1.85
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pimelil-(acil-nosilac protein) metil estarska esteraza (EC 3.1.1.85, BioH) je enzim sa sistematskim imenom pimelil-(acil-nosilac protein) metil estar hidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

pimelil-[acil-nosilac protein] metil estar + H2O pimelil-[acil-nosilac protein] + metanol

Ovaj enzim učestvuje u biosintezi biotina u Gram-negativim bakterijama.

Reference[uredi - уреди | uredi izvor]

  1. Sanishvili, R., Yakunin, A.F., Laskowski, R.A., Skarina, T., Evdokimova, E., Doherty-Kirby, A., Lajoie, G.A., Thornton, J.M., Arrowsmith, C.H., Savchenko, A., Joachimiak, A. and Edwards, A.M. (2003). "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". J. Biol. Chem. 278: 26039–26045. PMID 12732651. 
  2. Lemoine, Y., Wach, A. and Jeltsch, J.M. (1996). "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Mol. Microbiol. 19: 645–647. PMID 8830257. 
  3. Tomczyk, N.H., Nettleship, J.E., Baxter, R.L., Crichton, H.J., Webster, S.P. and Campopiano, D.J. (2002). "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Lett. 513: 299–304. PMID 11904168. 
  4. Lin, S., Hanson, R.E. and Cronan, J.E. (2010). "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nat. Chem. Biol.: –. PMID 20693992. 

Literatura[uredi - уреди | uredi izvor]

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