Peptidna deformilaza

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Peptidna deformilaza
EC broj
CAS broj 369636-51-1
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Peptidna deformilaza (EC, Peptide deformylase) je enzim sa sistematskim imenom formil-L-metionil peptid amidohidrolaza.[1][2][3][4][5][6][7][8][9][10][11][12] Ovaj enzim katalizuje sledeću hemijsku reakciju

formil-L-metionil peptid + H2O format + metionil peptid

Za dejstvo ovog enzima je neophodno prisustvo Fe(II).

Reference[uredi - уреди | uredi izvor]

  1. Adams, J.M. (1968). "On the release of the formyl group from nascent protein". J. Mol. Biol. 33: 571–589. PMID 4973445. 
  2. Mazel, D., Pochet, S. and Marliere, P. (1994). "Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation". EMBO J. 13: 914–923. PMID 8112305. 
  3. Chan, M.K., Gong, W., Rajagopalan, P.T.R., Hao, B., Tsai, C.M. and Pei, D. (1997). "Crystal structure of the Escherichia coli peptide deformylase". Biochemistry 36: 13904–13909. PMID 9374869. 
  4. Becker, A., Schlichting, I., Kabsch, W., Schultz, S. and Wagner, A.F.V. (1998). "Structure of peptide deformylase and identification of the substrate binding site". J. Biol. Chem. 273: 11413–11416. PMID 9565550. 
  5. Becker, A., Schlichting, I., Kabsch, W., Groche, D., Schultz, S. and Wagner, A.F. (1998). "Iron center, substrate recognition, and mechanism of peptide deformylase". Nat. Struct. Biol. 5: 1053–1058. PMID 9846875. 
  6. Rajagopalan, P.T.R., Yu, X.C. and Pei, D. (1997). "Peptide deformylase: a new type of mononuclear iron protein". J. Am. Chem. Soc. 119: 12418–12419. 
  7. Groche, D., Becker, A., Schlichting, I., Kabsch, W., Schultz, S. and Wagner, A.F.V. (1998). "Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site". Biochem. Biophys. Res. Commun. 246: 342–346. PMID 9610360. 
  8. Rajagopalan, P.T.R., Grimme, S. and Pei, D. (2000). "Characterization of cobalt(II)-substituted peptide deformylase: function of the metal ion and the catalytic residue Glu-133". Biochemistry 39: 779–790. PMID 10651644. 
  9. Hu, Y.J., Wei, Y., Zhou, Y., Rajagopalan, P.T.R. and Pei, D. (1999). "Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library". Biochemistry 38: 643–650. PMID 9888804. 
  10. Ragasu, S., Mouchet, P., Lazennec, C., Dive, V. and Meinnel, T. (1999). "Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin". J. Mol. Biol. 289: 1445–1457. PMID 10373378. 
  11. Giglione, C., Pierre, M. and Meinnel, T. (2000). "Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents". Mol. Microbiol. 36: 1197–1205. PMID 10931273. 
  12. Pei, D. (2001). "Peptide deformylase: a target for novel antibiotics?". Emerging Therapeutic Targets 5: 23–40. PMID 15992166. 

Literatura[uredi - уреди | uredi izvor]

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