Peptidaza Do

Peptidaza Do
	Peptidaza Do homo24mer, E.Coli
Identifikatori
EC broj	3.4.21.107
CAS broj	161108-11-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Peptidaza Do (EC 3.4.21.107, DegP, DegP proteaza, HtrA, proteaza A sa zahtevom za visoku temperaturu, HrtA protein toplotnog šoka, proteaza Do, Do proteaza) je enzim.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Ovaj enzim deluje na supstrate koji su bar delimično denaturisani. P1 ostatak mesta razlaganje je normalno između para hidrofobnih ostataka, kao što su Val-Val

Ova serinska endopeptidaza je esencijalna za razlaganje denaturisanih ili agregiranih proteina sa unutrašnje membrane i periplazmičnog prostora u Escherichia coli.

Reference[uredi - уреди | uredi izvor]

↑ Lipinska, B., Zylicz, M. and Georgopoulos, C. (1990). "The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase". J. Bacteriol. 172: 1791–1797. PMID 2180903.
↑ Seol, J.H., Woo, S.K., Jung, E.M., Yoo, S.J., Lee, C.S., Kim, K.J., Tanaka, K., Ichihara, A., Ha, D.B. and Chung, C.H. (1991). "Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product". Biochem. Biophys. Res. Commun. 176: 730–736. PMID 2025286.
↑ Jones, C.H., Dexter, P., Evans, A.K., Liu, C., Hultgren, S.J. and Hruby, D.E. (2002). "Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin". J. Bacteriol. 184: 5762–5771. PMID 12270835.
↑ Swamy, K.H., Chung, C.H. and Goldberg, A.L. (1983). "Isolation and characterization of protease Do from Escherichia coli, a large serine protease containing multiple subunits". Arch. Biochem. Biophys. 224: 543–554. PMID 6347072.
↑ Pallen, M.J. and Wren, B.W. (1997). "The HtrA family of serine proteases". Mol. Microbiol. 26: 209–221. PMID 9383148.
↑ Krojer, T., Garrido-Franco, M., Huber, R., Ehrmann, M. and Clausen, T. (2002). "Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine". Nature 416: 455–459. PMID 11919638.

Literatura[uredi - уреди | uredi izvor]

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.

Spoljašnje veze[uredi - уреди | uredi izvor]

MeSH Peptidase+Do

[1] Lipinska, B., Zylicz, M. and Georgopoulos, C. (1990). "The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase". J. Bacteriol. 172: 1791–1797. PMID 2180903.

[2] Seol, J.H., Woo, S.K., Jung, E.M., Yoo, S.J., Lee, C.S., Kim, K.J., Tanaka, K., Ichihara, A., Ha, D.B. and Chung, C.H. (1991). "Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product". Biochem. Biophys. Res. Commun. 176: 730–736. PMID 2025286.

[3] Jones, C.H., Dexter, P., Evans, A.K., Liu, C., Hultgren, S.J. and Hruby, D.E. (2002). "Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin". J. Bacteriol. 184: 5762–5771. PMID 12270835.

[4] Swamy, K.H., Chung, C.H. and Goldberg, A.L. (1983). "Isolation and characterization of protease Do from Escherichia coli, a large serine protease containing multiple subunits". Arch. Biochem. Biophys. 224: 543–554. PMID 6347072.

[5] Pallen, M.J. and Wren, B.W. (1997). "The HtrA family of serine proteases". Mol. Microbiol. 26: 209–221. PMID 9383148.

[6] Krojer, T., Garrido-Franco, M., Huber, R., Ehrmann, M. and Clausen, T. (2002). "Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine". Nature 416: 455–459. PMID 11919638.

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Peptidaza Do

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

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