Ovaj enzim deluje na supstrate koji su bar delimično denaturisani. P1 ostatak mesta razlaganje je normalno između para hidrofobnih ostataka, kao što su Val-Val
Ova serinska endopeptidaza je esencijalna za razlaganje denaturisanih ili agregiranih proteina sa unutrašnje membrane i periplazmičnog prostora u Escherichia coli.
↑Lipinska, B., Zylicz, M. and Georgopoulos, C. (1990). "The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase". J. Bacteriol.172: 1791–1797. PMID2180903.
↑Seol, J.H., Woo, S.K., Jung, E.M., Yoo, S.J., Lee, C.S., Kim, K.J., Tanaka, K., Ichihara, A., Ha, D.B. and Chung, C.H. (1991). "Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product". Biochem. Biophys. Res. Commun.176: 730–736. PMID2025286.
↑Jones, C.H., Dexter, P., Evans, A.K., Liu, C., Hultgren, S.J. and Hruby, D.E. (2002). "Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin". J. Bacteriol.184: 5762–5771. PMID12270835.
↑Swamy, K.H., Chung, C.H. and Goldberg, A.L. (1983). "Isolation and characterization of protease Do from Escherichia coli, a large serine protease containing multiple subunits". Arch. Biochem. Biophys.224: 543–554. PMID6347072.
↑Pallen, M.J. and Wren, B.W. (1997). "The HtrA family of serine proteases". Mol. Microbiol.26: 209–221. PMID9383148.
↑Krojer, T., Garrido-Franco, M., Huber, R., Ehrmann, M. and Clausen, T. (2002). "Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine". Nature416: 455–459. PMID11919638.