Paromamin 6'-oksidaza
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| Paromamin 6'-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.3.43 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Paromamin 6'-oksidaza (EC 1.1.3.43, btrQ (gen), neoG (gen), kanI (gen), tacB (gen)) je enzim sa sistematskim imenom paromamin:kiseonik 6'-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- paromamin + O2 6'-dehidroparomamin +H2O2
Ovaj enzim sadrži FAD. On učestvuje u biosintetičkom putu nekoliko klinički važnih aminociklitolnih antibiotika, uključujući kanamicin, butirozin, neomicin i riboztamicin. Ovaj enzim radi u kombinaciji sa EC 2.6.1.93, neaminskom transaminazom, da zameni 6'-hidroksi grupu paromamina sa amino grupom. Enzim iz bakterije Streptomyces fradiae takođe katalizuje reakciju enzima EC 1.1.3.44, 6-hidroksineomicin C oksidaza.
Reference[uredi | uredi kod]
- ↑ Huang, F., Spiteller, D., Koorbanally, N.A., Li, Y., Llewellyn, N.M. and Spencer, J.B. (2007). „Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin”. ChemBioChem. 8: 283-288. PMID 17206729.
- ↑ Yu, Y., Hou, X., Ni, X. and Xia, H. (2008). „Biosynthesis of 3′-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption”. J. Antibiot. (Tokyo) 61: 63-69. PMID 18408324.
- ↑ Clausnitzer, D., Piepersberg, W. and Wehmeier, U.F. (2011). „The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin”. J. Appl. Microbiol. 111: 642-651. PMID 21689223.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.