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Pankreasna elastaza

Izvor: Wikipedija
Pankreasna elastaza
Identifikatori
EC broj 3.4.21.36
CAS broj 2594837
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Pankreasna elastaza (EC 3.4.21.36, pankreatopeptidaza E, pankreasna elastaza I, elastaza, elaszim, serinska elastaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina, uključujući elastin. Preferentno odvajanje: Ala-

Ovaj enzim se formira aktivacijom proelastaze iz pankreasa sisara tripsinom.

Reference

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  1. Shotton, D.M. (1970). „Elastase”. Methods Enzymol. 19: 113-140. 
  2. Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. (1984). „Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus' protease V-8 using tripeptide thiobenzyl ester substrates”. Biochemistry 23: 2995-3002. PMID 6380580. 
  3. Kawashima, I., Tani, T., Shimoda, K. and Takiguchi, Y. (1987). „Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas”. DNA 6: 163-172. PMID 3646943. 
  4. Bieth, J.G., Dirrig, S., Jung, M.-L., Boudier, C., Papamichael, E., Sakarellos, C. and Dimicoli, J.-L. (1989). „Investigation of the active center of rat pancreatic elastase”. Biochim. Biophys. Acta 994: 64-74. PMID 2909256. 
  5. Bode, W., Meyer, E., Jr. and Powers, J.C. (1989). „Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors”. Biochemistry 28: 1951-1963. PMID 2655701. 

Literatura

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Spoljašnje veze

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