PPP1R9B
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Neurabin-2 je protein koji je kod ljudi kodiran PPP1R9B genom.[1][2]
Spinofilin je regulatorni deo katalitičke jedinica proteinske fosfataze-1 (PP1). On je visoko izražen u dendritskim izbočinama, specijalizoanim delovima koji primaju veći deo ekscitatornog unosa u centralnom nervnom sistemu.[2]
Interakcije[uredi | uredi kod]
PPP1R9B formira interakcije sa PPP1CB,[3] PPP1CA,[3] Dopamine receptor D2,[4] P16,[5] PPP1CC,[3][4] TIAM1[6] i PPP1R2.[7]
Reference[uredi | uredi kod]
- ↑ Allen PB, Ouimet CC, Greengard P (Oct 1997). „Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines”. Proc Natl Acad Sci U S A 94 (18): 9956–61. DOI:10.1073/pnas.94.18.9956. PMC 23308. PMID 9275233.
- ↑ 2,0 2,1 „Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B”.
- ↑ 3,0 3,1 3,2 Hsieh-Wilson, L C; Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry (UNITED STATES) 38 (14): 4365–73. DOI:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
- ↑ 4,0 4,1 Smith, F D; Oxford G S, Milgram S L (July 1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. (UNITED STATES) 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.
- ↑ Vivo, M; Calogero R A, Sansone F, Calabrò V, Parisi T, Borrelli L, Saviozzi S, La Mantia G (April 2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. (United States) 276 (17): 14161–9. DOI:10.1074/jbc.M006845200. ISSN 0021-9258. PMID 11278317.
- ↑ Buchsbaum, Rachel J; Connolly Beth A, Feig Larry A (May 2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. (United States) 278 (21): 18833–41. DOI:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897.
- ↑ Terry-Lorenzo, Ryan T; Elliot Elizabeth, Weiser Douglas C, Prickett Todd D, Brautigan David L, Shenolikar Shirish (November 2002). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. (United States) 277 (48): 46535–43. DOI:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.
Literatura[uredi | uredi kod]
- Burnett PE, Blackshaw S, Lai MM, et al. (1998). „Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton”. Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351–6. DOI:10.1073/pnas.95.14.8351. PMC 20979. PMID 9653190.
- Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). „Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1”. Biochemistry 38 (14): 4365–73. DOI:10.1021/bi982900m. PMID 10194355.
- Smith FD, Oxford GS, Milgram SL (1999). „Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein”. J. Biol. Chem. 274 (28): 19894–900. DOI:10.1074/jbc.274.28.19894. PMID 10391935.
- Stephens DJ, Banting G (1999). „Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin”. J. Biol. Chem. 274 (42): 30080–6. DOI:10.1074/jbc.274.42.30080. PMID 10514494.
- Richman JG, Brady AE, Wang Q, et al. (2001). „Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin”. J. Biol. Chem. 276 (18): 15003–8. DOI:10.1074/jbc.M011679200. PMID 11154706.
- Vivo M, Calogero RA, Sansone F, et al. (2001). „The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein”. J. Biol. Chem. 276 (17): 14161–9. DOI:10.1074/jbc.M006845200. PMID 11278317.
- Grossman SD, Hsieh-Wilson LC, Allen PB, et al. (2003). „The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines”. Neuromolecular Med. 2 (1): 61–9. DOI:10.1385/NMM:2:1:61. PMID 12230305.
- Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). „Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton”. J. Biol. Chem. 277 (48): 46535–43. DOI:10.1074/jbc.M206960200. PMID 12270929.
- Hsieh-Wilson LC, Benfenati F, Snyder GL, et al. (2003). „Phosphorylation of spinophilin modulates its interaction with actin filaments”. J. Biol. Chem. 278 (2): 1186–94. DOI:10.1074/jbc.M205754200. PMID 12417592.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Buchsbaum RJ, Connolly BA, Feig LA (2003). „Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin”. J. Biol. Chem. 278 (21): 18833–41. DOI:10.1074/jbc.M207876200. PMID 12531897.
- Tsukada M, Prokscha A, Oldekamp J, Eichele G (2004). „Identification of neurabin II as a novel doublecortin interacting protein”. Mech. Dev. 120 (9): 1033–43. DOI:10.1016/S0925-4773(03)00177-1. PMID 14550532.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Law AJ, Weickert CS, Hyde TM, et al. (2004). „Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines”. The American journal of psychiatry 161 (10): 1848–55. DOI:10.1176/appi.ajp.161.10.1848. PMID 15465982.
