PB28
(Preusmjereno sa stranice PB-28)
| PB-28 | |||
|---|---|---|---|
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| IUPAC ime |
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| Drugi nazivi | PB28 | ||
| Identifikacija | |||
| CAS registarski broj | 172906-90-0 | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C24H38N2O | ||
| Molarna masa | 370.57 g/mol | ||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
PB-28[1] je agonist sigma-2 receptora.[2][3][4][5][6]
On je izveden iz cikloheksil-piperazina.
Literatura[uredi | uredi kod]
- ↑ Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). „New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives”. J. Med. Chem. 39 (1): 176–82. DOI:10.1021/jm950409c. PMID 8568804.
- ↑ Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). „The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells”. Cell Calcium 40 (1): 23–8. DOI:10.1016/j.ceca.2006.03.004. PMID 16687172.
- ↑ Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). „Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer”. Mol. Cancer Ther. 5 (7): 1807–16. DOI:10.1158/1535-7163.MCT-05-0402. PMID 16891467.
- ↑ Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R (July 2006). „Is the sigma2 receptor a histone binding protein?”. Journal of Medicinal Chemistry 49 (14): 4153–8. DOI:10.1021/jm0600592. PMID 16821775.
- ↑ Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R (December 2009). „Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)”. Journal of Medicinal Chemistry 52 (23): 7817–28. DOI:10.1021/jm9007505. PMID 19842660.
- ↑ Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA (February 2010). „Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer”. Chemmedchem 5 (2): 268–73. DOI:10.1002/cmdc.200900402. PMID 20077462.
