Opin dehidrogenaza
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| Opin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.28 | ||||||||
| CAS broj | 108281-02-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Opin dehidrogenaza (EC 1.5.1.28, (2S)-2(1-(R)-karboksietil)amino}pentanoat dehidrogenaza (NAD+, formira L-aminopentanoat)) je enzim sa sistematskim imenom (2S)-2(1-(R)-karboksietil)amino}pentanoat:NAD+ oksidoreduktaza (formira L-aminopentanoat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S)-2-{[1-(R)-karboksietil]amino}pentanoat + NAD+ +H2O L-2-aminopentanoinska kiselina + piruvat + NADH + H+
Enzim iz Arthrobacter sp. takođe deluje na sekundarni amin dikarboksilata kao što su N-(1-karboksietil)metionin i N-(1-karboksietil)fenilalanin.
Reference[uredi | uredi kod]
- ↑ Asano, Y., Yamaguchi, K. and Kondo, K. (1989). „A new NAD+-dependent opine dehydrogenase from Arthrobacter sp. strain 1C”. J. Bacteriol. 171: 4466-4471. PMID 2753861.
- ↑ Dairi, T. and Asano, Y. (1995). „Cloning, nucleotide sequencing, and expression of an opine dehydrogenase gene from Arthrobacter sp. strain 1C”. Appl. Environ. Microbiol. 61: 3169-3171. PMID 7487048.
- ↑ Kato, Y., Yamada, H. and Asano, Y. (1996). „Stereoselective synthesis of opine-type secondary amine carboxylic acids by a new enzyme opine dehydrogenase. Use of recombinant enzymes”. J. Mol. Catal., B Enzym. 1: 151-160.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.