O-aminofenol oksidaza
Prijeđi na navigaciju
Prijeđi na pretragu
| O-aminofenol oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.10.3.4 | ||||||||
| CAS broj | 9013-85-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
O-aminofenol oksidaza (EC 1.10.3.4, izofenoksazinska sintaza, o-aminofenol:O2 oksidoreduktaza, 2-aminofenol:O2 oksidoreduktaza, GriF) je enzim sa sistematskim imenom 2-aminofenol:kiseonik oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 2-aminofenol + O2 + akceptor 2-aminofenoksazin-3-on + redukovani akceptor + 2H2O (sveukupna reakcija)
- (1a) 2 2-aminofenol + O2 2 6-iminocikloheksa-2,4-dienon + 2H2O
- (1b) 2 6-iminocikloheksa-2,4-dienon + akceptor 2-aminofenoksazin-3-on + redukovani akceptor (spontana reakcija)
Ovaj enzim je flavoprotein.
Reference[uredi | uredi kod]
- ↑ Nair, P.M. and Vaidynathan, C.S. (1964). „Isophenoxazine synthase”. Biochim. Biophys. Acta 81: 507-516. PMID 14170322.
- ↑ Nair, P.M. and Vining, L.C. (1965). „Isophenoxazine synthase apoenzyme from Pycnoporus coccineus”. Biochim. Biophys. Acta 96: 318-327. PMID 14298835.
- ↑ Subba Rao, P.V. and Vaidyanathan, C.S. (1967). „Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra”. Arch. Biochem. Biophys. 118: 388-394. PMID 4166439.
- ↑ Suzuki, H., Furusho, Y., Higashi, T., Ohnishi, Y. and Horinouchi, S. (2006). „A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone”. J. Biol. Chem. 281: 824-833. PMID 16282322.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.