Nuklearna inkluziona a endopeptidaza
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| Nuklearna inkluziona a endopeptidaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.4.22.44 | ||||||||
| CAS broj | 139946-51-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nuklearna inkluziona a endopeptidaza (EC 3.4.22.44, potivirusna NIa proteaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Ovi enzimi hidrolizuju glutaminske veze. Njehove aminokiselinske preferencije u P6 - P1' poziciji su zavisne od vrste potivirusa, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-(Ser ili Gly) za enzim iz tobacco etch virusa. Prirodni supstrat je viralni poliprotein, mada deluje na druge proteine i oligopeptide sa odgovarajućom konsensus sekvencom.
Potivirusi uzrokuju bolesti biljki, i inkluziona tela se javljaju u jedru ćelije domačina. Protein inkluzionih tela je endopeptidaza.
Reference[uredi | uredi kod]
- ↑ Fellers, J.P., Collins, G.B. and Hunt, A.G. (1998). „The NIa-proteinase of different plant potyviruses provides specific resistance to viral infection”. Crop Sci. 38: 1309-1319.
- ↑ Kim, D.-H. and Choi, K.Y. (1998). „Potyvirus NIa protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 721-723.
- ↑ Takahashi, T., Nakanishi, M., Yao, Y., Uyeda, I. and Serizawa, N. (1998). „Direct formation of human interleukin-11 by cis-acting system of plant virus protease in Escherichia coli”. Biosci. Biotechnol. Biochem. 62: 953-958. PMID 9648226.
- ↑ Kim, D.H., Hwang, D.C., Kang, B.H., Lew, J., Han, J.S., Song, B.O.D. and Choi, K.Y. (1996). „Effects of internal cleavages and mutations in the C-terminal region of NIa protease of turnip mosaic potyvirus on the catalytic activity”. Virology 226: 183-190. PMID 8955037.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Kim, D.-H. and Choi, K.Y. (1998). „Potyvirus NIa protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 721-723.