Nitrohinolin-N-oksid reduktaza
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| Nitrohinolin-N-oksid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.1.9 | ||||||||
| CAS broj | 37256-35-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nitrohinolin-N-oksid reduktaza (EC 1.7.1.9, 4-nitrohinolin 1-oksidna reduktaza, 4NQO reduktaza, NAD(P)H2:4-nitrohinolin-N-oksidna oksidoreduktaza) je enzim sa sistematskim imenom 4-(hidroksiamino)hinolin N-oksid:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-(hidroksiamino)hinolin N-oksid + 2 NAD(P)+ +H2O 4-nitrohinolin N-oksid + 2 NAD(P)H + 2 H+
Reference[uredi | uredi kod]
- ↑ Toriyama, N. (1965). „[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide]”. Nichidai Igaku Zasshi 24: 423-432.
- ↑ Stanley, J.S., York, J.L. and Benson, A.M. (1992). „Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice”. Cancer Res. 52: 58-63. PMID 1370076.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.