Nitrilotriacetat monooksigenaza
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| Nitrilotriacetat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.14.10 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Nitrilotriacetat monooksigenaza (EC 1.14.14.10, nitrilotriacetatna monooksigenaza) je enzim sa sistematskim imenom nitrilotriacetat,FMNH2:kiseonik oksidoreduktaza (formiranje glioksilata).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nitrilotriacetat + FMNH2 + H+ + O2 iminodiacetat + glioksilat + FMN + H2O
Za rad ovog enzim je neophodan Mg2+. Enzim iz Aminobacter aminovorans je deo dvokomponentnog sistema koji takođe obuhvata EC 1.5.1.42 (FMN reduktazu), koja pruža redukovani flavinski mononukleotid ovom enzimu.
Reference[uredi | uredi kod]
- ↑ Uetz, T., Schneider, R., Snozzi, M. and Egli, T. (1992). „Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600”. J. Bacteriol. 174: 1179-1188. PMID 1735711.
- ↑ Knobel, H.R., Egli, T. and van der Meer, J.R. (1996). „Cloning and characterization of the genes encoding nitrilotriacetate monooxygenase of Chelatobacter heintzii ATCC 29600”. J. Bacteriol. 178: 6123-6132. PMID 8892809.
- ↑ Xu, Y., Mortimer, M.W., Fisher, T.S., Kahn, M.L., Brockman, F.J. and Xun, L. (1997). „Cloning, sequencing, and analysis of a gene cluster from Chelatobacter heintzii ATCC 29600 encoding nitrilotriacetate monooxygenase and NADH:flavin mononucleotide oxidoreductase”. J. Bacteriol. 179: 1112-1116. PMID 9023192.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.