Nisko-specifična L-treoninska aldolaza

Izvor: Wikipedia
Nisko-specifična L-treoninska aldolaza
Identifikatori
EC broj 4.1.2.48
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Nisko-specifična L-treoninska aldolaza (EC 4.1.2.48, LtaE) je enzim sa sistematskim imenom L-treonin/L-allo-treonin acetaldehid-lijaza (formira glicin).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) L-treonin \rightleftharpoons glicin + acetaldehid
(2) L-allo-treonin \rightleftharpoons glicin + acetaldehid

Za dejstvo ovog enzima je neophodan piridoksal fosfat.

Reference[uredi - уреди]

  1. Yamada, H., Kumagai, H., Nagate, T. and Yoshida, H. (1970). "Crystalline threonine aldolase from Candida humicola". Biochem. Biophys. Res. Commun. 39: 53–58. PMID 5438301. 
  2. Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H. (1972). "Threonine aldolase from Candida humicola. II. Purification, crystallization and properties". Biochim. Biophys. Acta 258: 779–790. PMID 5017702. 
  3. Liu, J.Q., Nagata, S., Dairi, T., Misono, H., Shimizu, S. and Yamada, H. (1997). "The GLY1 gene of Saccharomyces cerevisiae encodes a low-specific L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine–expression of the gene in Escherichia coli and purification and characterization of the enzyme". Eur. J. Biochem. 245: 289–293. PMID 9151955. 
  4. Liu, J.Q., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S. and Yamada, H. (1998). "Gene cloning, biochemical characterization and physiological role of a thermostable low-specificity L-threonine aldolase from Escherichia coli". Eur. J. Biochem. 255: 220–226. PMID 9692922. 
  5. Kim, J., Kershner, J.P., Novikov, Y., Shoemaker, R.K. and Copley, S.D. (2010). "Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis". Mol. Syst. Biol. 6: #436–436. PMID 21119630. 

Literatura[uredi - уреди]

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