Nikotinat dehidrogenaza
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| Nikotinat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.1.5 | ||||||||
| CAS broj | 2614835 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nikotinat dehidrogenaza (EC 1.17.1.5, nikotinsko kiselinska hidroksilaza, nikotinatna hidroksilaza) je enzim sa sistematskim imenom nikotinat:NADP+ 6-oksidoreduktaza (hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- nikotinat + H2O + NADP+ 6-hidroksinikotinat + NADPH + H+
Ovaj enzim je flavoprotein koji sadrži gvožđe nevezano za hem. Enzim ima sposobnost aktiviranja mnoštva nikotinatnih analoga u različitim merama.
Reference[uredi | uredi kod]
- ↑ Holcenberg, J.S. and Stadtman, E.R. (1969). „Nicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase”. J. Biol. Chem. 244: 1194-1203. PMID 4388026.
- ↑ Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1996). „Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri”. Biochemistry 35: 212-223. PMID 8555176.
- ↑ Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1994). „Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme”. Proc. Natl. Acad. Sci. USA 91: 232-236. PMID 8278371.
- ↑ Dilworth, G.L. (1983). „Occurrence of molybdenum in the nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 221: 565-569. PMID 6838209.
- ↑ Dilworth, G.L. (1982). „Properties of the selenium-containing moiety of nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 219: 30-38. PMID 7181513.
- ↑ Nagel, M. and Andreesen, J.R. (1990). „Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini”. Arch. Microbiol. 154: 605-613.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.