Nespecifična monooksigenaza

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Nespecifična monooksigenaza
EC broj
CAS broj 9038-14-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Nespecifična monooksigenaza (EC, microsomal monooksigenaza, ksenobiotik monooksigenaza, aril-4-monooksigenaza, aril hidrokarbon hidroksilaza, microsomal P-450, flavoprotein-vezani monooksigenaza, flavoprotein monooksigenaza) je enzim sa sistematskim imenom supstrat,redukovani-flavoprotein:kiseonik oksidoreduktaza (RH-hidroksilacija or -epoksidacija).[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Ovaj enzim katalizuje sledeću hemijsku reakciju

RH + redukovani flavoprotein + O2 ROH + oksidovani flavoprotein + H2O

Nespecifična monooksigenaza je grupa hem-tiolatnih proteina (P-450), koji deluju na širok opseg supstrata uključujući mnoge ksenobiotike, steroide, masne kiseline, vitamine i prostaglandine.

Reference[uredi - уреди | uredi izvor]

  1. Booth, J. and Boyland, E. (1957). "The biochemistry of aromatic amines. 3. Enzymic hydroxylation by rat-liver microsomes". Biochem. J. 66: 73–78. PMID 13426111. 
  2. Fujita, T. and Mannering, G.J. (1971). "Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene". Chem. Biol. Interact. 3: 264–265. PMID 5132997. 
  3. Haugen, D.A. and Coon, M.J. (1976). "Properties of electrophoretically homogeneous phenobarbital-inducible and β-naphthoflavone-inducible forms of liver microsomal cytochrome P-450". J. Biol. Chem. 251: 7929–7939. PMID 187601. 
  4. Imaoka, S., Inoue, K. and Funae, Y. (1988). "Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography". Arch. Biochem. Biophys. 265: 159–170. PMID 3415241. 
  5. Johnson, E.F., Zounes, M. and Müller-Eberhard, U. (1979). "Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis". Arch. Biochem. Biophys. 192: 282–289. PMID 434823. 
  6. Kupfer, D., Miranda, G.K., Navarro, J., Piccolo, D.E. and Theoharides, A.D. (1979). "Effect of inducers and inhibitors of monooxygenase on the hydroxylation of prostaglandins in the guinea pig. Evidence for several monooxygenases catalyzing ω- and ω-1-hydroxylation". J. Biol. Chem. 254: 10405–10414. PMID 489601. 
  7. Lang, M.A., Gielen, J.E. and Nebert, D.W. (1981). "Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice". J. Biol. Chem. 256: 12068–12075. PMID 7298645. 
  8. Lang, M.A. and Nebert, D.W. (1981). "Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes". J. Biol. Chem. 256: 12058–12075. PMID 7298644. 
  9. Leo, M.A., Lasker, J.M., Rauby, J.L., Kim, C.I., Black, M. and Lieber, C.S. (1989). "Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8". Arch. Biochem. Biophys. 269: 305–312. PMID 2916844. 
  10. Lu, A.Y.H., Kuntzman, S.W., Jacobson, M. and Conney, A.H. (1972). "Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations". J. Biol. Chem. 247: 1727–1734. PMID 4401153. 
  11. Mitoma, C., Posner, H.S., Reitz, H.C. and Udenfriend, S. (1956). "Enzymic hydroxylation of aromatic compounds". Arch. Biochem. Biophys. 61: 431–441. PMID 13314626. 
  12. Mitoma, C. and Udenfriend, S. (1962). "Aryl-4-hydroxylase". Methods Enzymol. 5: 816–819. 
  13. Napoli, J.L., Okita, R.T., Masters, B.S. and Horst, R.L. (1981). "Identification of 25,26-dihydroxyvitamin D3 as a rat renal 25-hydroxyvitamin D3 metabolite". Biochemistry 20: 5865–5871. PMID 7295706. 
  14. Nebert, D.W. and Gelboin, H.V. (1968). "Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme". J. Biol. Chem. 243: 6242–6249. PMID 4387094. 
  15. Suhara, K., Ohashi, K., Takahashi, K. and Katagiri, M. (1988). "Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrial P-450(11)beta". Arch. Biochem. Biophys. 267: 31–37. PMID 3264134. 
  16. Theoharides, A.D. and Kupfer, D. (1981). "Evidence for different hepatic microsomal monooxygenases catalyzing ω- and (ω-1)-hydroxylations of prostaglandins E1 and E2. Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation". J. Biol. Chem. 256: 2168–2175. PMID 7462235. 
  17. Thomas, P.E., Lu, A.Y.H., Ryan, D., West, S.B., Kawalek, J. and Levin, W. (1976). "Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448". Mol. Pharmacol. 12: 746–758. PMID 825720. 

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