Naftalen 1,2-dioksigenaza
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| Naftalen 1,2-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.12 | ||||||||
| CAS broj | 2620349 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Naftalen 1,2-dioksigenaza (EC 1.14.12.12, naftalenska dioksigenaza, naftalenska oksigenaza, NDO) je enzim sa sistematskim imenom naftalen,NADH:kiseonik oksidoreduktaza (1,2-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- naftalen + NADH + H+ + O2 (1R,2S)-1,2-dihidronaftalen-1,2-diol + NAD+
Ovaj enzim je član familije dioksigenaza koji vrše hidroksilaciju prstena. Ovi bakterijski enzimi imaju kritičnu ulogu u degradaciji aromatičnih jedinjenja.
Reference[uredi | uredi kod]
- ↑ Ensley, B.D. and Gibson, D.T. (1983). „Naphthalene dioxygenase: purification and properties of a terminal oxygenase component”. J. Bacteriol. 155: 505-511. PMID 6874638.
- ↑ Jeffrey, A.M., Yeh, H.J.C., Jerina, D.M., Patel, T.R., Davey, J.F. and Gibson, D.T. (1975). „Initial reactions in the oxidation of naphthalene by Pseudomonas putida”. Biochemistry 14: 575-584. PMID 234247.
- ↑ Kauppi, B., Lee, K., Carredano, E., Parales, R.E., Gibson, D.T., Eklund, H. and Ramaswamy, S. (1998). „Structure of an aromatic-ring-hydroxylating dioxygenase - naphthalene 1,2-dioxygenase”. Structure 6: 571-586. PMID 9634695.
- ↑ Parales, R.E., Lee, K., Resnick, S.M., Jiang, H., Lessner, D.J. and Gibson, D.T. (2000). „Substrate specificity of naphthalene dioxygenase: effect of specific amino acids at the active site of the enzyme”. J. Bacteriol. 182: 1641-1649. PMID 10692370.
- ↑ Jouanneau, Y., Meyer, C., Jakoncic, J., Stojanoff, V. and Gaillard, J. (2006). „Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons”. Biochemistry 45: 12380-12391. PMID 17014090.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.