NAD+—diftamid ADP-riboziltransferaza
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| NAD+—diftamid ADP-riboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.36 | ||||||||
| CAS broj | 52933-21-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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NAD+—diftamid ADP-riboziltransferaza (EC 2.4.2.36, ADP-riboziltransferaza, mono(ADPribozil)transferaza, NAD—diphthamid ADP-riboziltransferaza) je enzim sa sistematskim imenom NAD+:peptid-difthamid N-(ADP-D-ribozil)transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- NAD+ + peptid difthamid nikotinamid + peptid N-(ADP-D-ribozil)diphthamid
Toksin diftherije i neki drugi bakterijski toksini katalizuju ovu reakciju.
Reference[uredi | uredi kod]
- ↑ Lee, H. and Iglewski, W.J. (1984). „Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A”. Proc. Natl. Acad. Sci. USA 81: 2703-2707. PMID 6326138.
- ↑ Ueda, K. and Hayaishi, O. (1985). „ADP-ribosylation”. Annu. Rev. Biochem. 54: 73-100. PMID 3927821.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.