N-acetilneuraminat sintaza
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| N-acetilneuraminat sintaza | |||||||||
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| N-acetilneuraminat sintaza dimer, Neisseria meningitidis | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.56 | ||||||||
| CAS broj | 37290-66-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acetilneuraminat sintaza (EC 2.5.1.56, (NANA) kondenzujući enzim, N-acetilneuraminat piruvat-lijaza (piruvatna fosforilacija), NeuAc sintaza) je enzim sa sistematskim imenom fosfoenolpiruvat:N-acetil-D-manozamin C-(1-karboksivinil)transferaza (fosfatna hidroliza, formira 2-karboksi-2-oksoetil).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfoenolpiruvat + N-acetil-D-manozamin + H 2O fosfat + N-acetilneuraminat
Reference[uredi | uredi kod]
- ↑ Blacklow, R.S. and Warren, L. (1962). „Biosynthesis of sialic acids by Neisseria meningitidis”. J. Biol. Chem. 237: 3520-3526. PMID 13971393.
- ↑ Komaki, E., Ohta, Y. and Tsukada, Y. (1997). „Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12”. Biosci. Biotechnol. Biochem. 61: 2046-2050. PMID 9438985.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.