N-acetilgalaktozamin 4-sulfat 6-O-sulfotransferaza
Prijeđi na navigaciju
Prijeđi na pretragu
| N-acetilgalaktozamin 4-sulfat 6-O-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.33 | ||||||||
| CAS broj | 242469-38-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acetilgalaktozamin 4-sulfat 6-O-sulfotransferaza (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gen)) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(dermatan)-4-O-sulfo-N-acetil-D-galaktozamin 6-O-sulfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 3-fosfo-5-adenilil sulfat + [dermatan]-4-O-sulfo-N-acetil-D-galaktozamin adenozin 3',5'-bisfosfat + [dermatan]-4,6-di-O-sulfo-N-acetil-D-galaktozamin
- (2) 3-fosfo-5-adenilil sulfat + [hondroitin]-4-O-sulfon-acetil-D-galaktozamin adenozin 3',5'-bisfosfat + [hondroitin]-4,6-di-O-sulfo-N-acetil-D-galaktozamin
Ovaj enzim se aktivira dvovalentnim katjonom i redukovanim glutationom.
Reference[uredi | uredi kod]
- ↑ Ito, Y. and Habuchi, O. (2000). „Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage”. J. Biol. Chem. 275: 34728-34736. PMID 10871629.
- ↑ Ohtake, S., Ito, Y., Fukuta, M. and Habuchi, O. (2001). „Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene”. J. Biol. Chem. 276: 43894-43900. PMID 11572857.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.