N,N'-diacetilegionaminat sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| N,N'-diacetilegionaminat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.101 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N,N'-diacetilegionaminat sintaza (EC 2.5.1.101, neuB (gen), legI (gen)) je enzim sa sistematskim imenom fosfenolpiruvat:2,4-diacetamido-2,4,6-tridezoksi-alfa-D-mannopiranoza 1-(2-karboksi-2-oksoetil)transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2,4-diacetamido-2,4,6-tridezoksi-alfa-D-manopiranoza + fosfenolpiruvat + H2O N,N'-diacetillegionaminat + fosfat
Za dejstvo ovog enzima je neophodan divalentni metalni jon, poput Mn2+. Enzim je izolovan iz bakterija Legionella pneumophila i Campylobacter jejuni, gde učestvuje u biosinteza legionaminske kiseline.
Reference[uredi | uredi kod]
- ↑ Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). „Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila”. Biochemistry 47: 3272-3282. PMID 18275154.
- ↑ Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). „The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors”. Glycobiology 19: 715-725. PMID 19282391.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.