Morfin 6-dehidrogenaza
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| Morfin 6-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.218 | ||||||||
| CAS broj | 97002-71-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Morfin 6-dehidrogenaza (EC 1.1.1.218, naloksonksa reduktaza, reduktaza, nalokson) je enzim sa sistematskim imenom morfin:NAD(P)+ 6-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- morfin + NAD(P)+ morfinon + NAD(P)H + H+
Takođe deluje na neke druge alkaloide, uključujući kodein, normorfin i etilmorfin, ali samo veoma sporo na 7,8-zasićene derivate kao što su dihidromorfin i dihidrokodein. U reverznom smeru, takođe redukuje naloksone do 6alfa-hidroksi analoga. Ovaj enzim aktivira 2-merkaptoetanol.
Reference[uredi | uredi kod]
- ↑ Yamano, S., Kaguera, E., Ishida, T. and Toki, S. (1985). „Purification and characterization of guinea pig liver morphine 6-dehydrogenase”. J. Biol. Chem. 260: 5259-5264. PMID 2580834.
- ↑ Yamano, S., Nishida, F. and Toki, S. (1986). „Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase”. Biochem. Pharmacol. 35: 4321-4326. PMID 3539118.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.