Molibdopterin sintaza sumportransferaza
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| Molibdopterin sintaza sumportransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.11 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Molibdopterin sintaza sumportransferaza (EC 2.8.1.11, adenililtransferaza i sumportransferaza MOCS3, Cnx5 (gen), molibdopterin sintaza sumporilaza) je enzim sa sistematskim imenom persumporna L-cistein desumporaza:(molibdopterin-sintaza sumpor-nosilac protein)-Gly-Gly sumportransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- [molibdopterin-sintaza sumpor-nosilac protein]-Gly-Gly-AMP + [cistein desumporaza]-S-sulfanil-L-cistein AMP + [molibdopterin-sintaza sumpor-nosilac protein]-Gly-NH-CH2-C(O)SH + cistein desumporaza
Ovaj enzim prenosi sumpor i formira tiokarboksilatnu grupu na C-terminalnom glicinu male podjedinice enzima EC 2.8.1.12, molibdopterinske sintaze.
Reference[uredi | uredi kod]
- ↑ Matthies, A., Nimtz, M. and Leimkuhler, S. (2005). „Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry”. Biochemistry 44: 7912-7920. PMID 15910006.
- ↑ Leimkuhler, S. and Rajagopalan, K.V. (2001). „A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli”. J. Biol. Chem. 276: 22024-22031. PMID 11290749.
- ↑ Hanzelmann, P., Dahl, J.U., Kuper, J., Urban, A., Muller-Theissen, U., Leimkuhler, S. and Schindelin, H. (2009). „Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains”. Protein Sci. 18: 2480-2491. PMID 19798741.
- ↑ Dahl, J.U., Urban, A., Bolte, A., Sriyabhaya, P., Donahue, J.L., Nimtz, M., Larson, T.J. and Leimkuhler, S. (2011). „The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli”. J. Biol. Chem. 286: 35801-35812. PMID 21856748.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.