Molibdopterin sintaza
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| Molibdopterin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.12 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Molibdopterin sintaza (EC 2.8.1.12, MPT sintaza) je enzim sa sistematskim imenom tiokarboksilisana molibdopterin sintaza:ciklična piranopterin monofosfat sumportransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ciklični piranopterin monofosfat + 2 [molibdopterin-sintaza sumpor-nosilac protein]-Gly-NH-CH2-C(O)SH +H2O molibdopterin + 2 molibdopterin-sintaza sumpor-nosilac protein
Ovaj enzim katalizuje sintezu molibdopterina iz cikličnog piranopterin monofosfata.
Reference[uredi | uredi kod]
- ↑ Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V. and Schindelin, H. (2008). „Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency”. Biochemistry 47: 615-626. PMID 18092812.
- ↑ Wuebbens, M.M. and Rajagopalan, K.V. (2003). „Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis”. J. Biol. Chem. 278: 14523-14532. PMID 12571226.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.