Molekulski šaperon Hsc70 ATPaza
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Šaperon (protein) | |||||||||
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Identifikatori | |||||||||
EC broj | 3.6.4.10 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Šaperon (protein) (EC 3.6.4.10, molekulski šaperon Hsc70 ATPaza) je enzim sa sistematskim imenom ATP fosfohidrolaza (polimerizacija polipeptida).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ova veoma raznovrsna grupa enzima vrši mnoštvo funkcija koje su slične sa funkcijama šaperonina.
Reference[uredi | uredi kod]
- ↑ Sadis, S. and Hightower, L.E. (1992). „Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange”. Biochemistry 31: 9406-9412. PMID 1356434.
- ↑ Blond-Elquindi, S., Fourie, A.M., Sambrook, J.F. and Gething, M.J. (1993). „Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers”. J. Biol. Chem. 268: 12730-12735. PMID 8509407.
- ↑ Wawrzynow, A., Wojtkowiak, D., Marszalek, J., Banecki, B., Jonsen, M., Graves, B., Georgopoulos, C. and Zylicz, M. (1995). „The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone”. EMBO J. 14: 1867-1877. PMID 7743994.
- ↑ Sriram, M., Osipiuk, J., Freeman, B., Morimoto, R. and Joachimiak, A. (1997). „Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain”. Structure 5: 403-414. PMID 9083109.
- ↑ Li, X., Su, R.T., Hsu, H.T. and Sze, H. (1998). „The molecular chaperone calnexin associated with the vacuolar H+-ATPase from oat seedlings”. Plant Cell 10: 119-130. PMID 9477575.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.