Mikocerosat sintaza
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| Mikocerosat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.111 | ||||||||
| CAS broj | 95229-19-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mikocerosat sintaza (EC 2.3.1.111, sintaza mikocerozinske kiseline) je enzim sa sistematskim imenom acil-KoA:metilmalonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoil-redukcija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + n metilmalonil-KoA + 2n NADPH + 2n H+ multi-metil-branched acil-KoA + n KoA + n CO2 + 2n NADP+
Ovaj enzim produžava KoA estre masnih kiseline od C6 do C20 inkorporacijom metilmalonilnih ostataka, čime se formiraju multimetil-razgranate masna-acil-KoA kao što je 2,4,6,8-tetrametil-oktanoil-KoA.
Reference[uredi | uredi kod]
- ↑ Rainwater, D.L. and Kollattukudy, P.E. (1985). „Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA”. J. Biol. Chem. 260: 616-623. PMID 3880746.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.