Metionin-S-oksid reduktaza
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| Metionin-S-oksid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.4.5 | ||||||||
| CAS broj | 70248-65-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Metionin-S-oksid reduktaza (EC 1.8.4.5, metil sulfoksidna reduktaza I i II, acetilmetionin sulfoksidna reduktaza, metionin sulfoksidna reduktaza, L-metionin:oksidovani-tioredoksin S-oksidoreduktaza) je enzim sa sistematskim imenom L-metionin:tioredoksin-disulfid S-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-metionin + tioredoksin disulfid + H2O L-metionin S-oksid + tioredoksin
U reverznoj reakciji, ditiotreitol može da zameni redukovani tioredoksin.
Reference[uredi | uredi kod]
- ↑ Black, S., Harte, E.M., Hudson, B. and Wartofsky, L. (1960). „A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides”. J. Biol. Chem. 235: 2910-2916.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1979). „Reduction of methionine sulfoxide to methionine by Escherichia coli”. J. Bacteriol. 139: 161-164. PMID 37234.
- ↑ Ejiri, S.-I., Weissbach, H. and Brot, N. (1980). „The purification of methionine sulfoxide reductase from Escherichia coli”. Anal. Biochem. 102: 393-398. PMID 6999943.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.