Metiltetrahidroprotoberberin 14-monooksigenaza
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| Metiltetrahidroprotoberberin 14-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.37 | ||||||||
| CAS broj | 113478-42-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Metiltetrahidroprotoberberin 14-monooksigenaza (EC 1.14.13.37, metiltetrahidroprotoberberinska 14-hidroksilaza, (S)-cis-N-metiltetrahidroberberinska 14-monooksigenaza, (S)-cis-N-metiltetrahidroprotoberberin-14-hidroksilaza) je enzim sa sistematskim imenom (S)-N-metilkanadin,NADPH:kiseonik oksidoreduktaza (14-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-N-metilkanadin + NADPH + H+ + O2 alokriptopin + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450).
Reference[uredi | uredi kod]
- ↑ Rueffer, M. and Zenk, M.H. (1987). „Enzymatic formation of protopines by a microsomal cytochrome-P-450 system of Corydalis vaginans”. Tetrahedron Lett. 28: 5307-5310.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.