Metilornitinska sintaza
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| Metilornitinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.58 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Metilornitinska sintaza (EC 5.4.99.58, PylB) je enzim sa sistematskim imenom L-lizin karboksi-aminometilmutaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-lizin (3R)-3-metil-D-ornitin
Ovaj enzim je član superfamilije S-adenozil-L-metionin-zavisnih radikalskih enzima.
Reference[uredi | uredi kod]
- ↑ Gaston, M.A., Zhang, L., Green-Church, K.B. and Krzycki, J.A. (2011). „The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine”. Nature 471: 647-650. PMID 21455182.
- ↑ Quitterer, F., List, A., Eisenreich, W., Bacher, A. and Groll, M. (2012). „Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis”. Angew. Chem. Int. Ed. Engl. 51: 1339-1342. PMID 22095926.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.