Manozil-oligosaharid 1,3-1,6-alfa-manozidaza
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| Manozil-oligosaharid 1,3-1,6-alfa-manozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.114 | ||||||||
| CAS broj | 82047-77-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Manozil-oligosaharid 1,3-1,6-alfa-manozidaza (EC 3.2.1.114, manozidaza II, ekso-1,3-1,6-alfa-manozidaza, alfa-D-manozidaza II, alfa-manozidaza II, alfa1-3,6-manozidaza, GlcNAc transferaza I-zavisna alfa1,3(alfa1,6)manozidaza, Golgi alfa-manozidaza II, ManII, 1,3(1,6)-alfa-D-manozidaza, 1,3-(1,6-)manozil-oligosaharid alfa-D-manohidrolaza) je enzim sa sistematskim imenom (1->3)-(1->6)-manozil-oligosaharid alfa-D-manohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza terminalnih (1->3)- i (1->6)-vezanih alfa-D-manoznih ostataka i manozil-oligosaharidu Man5(GlcNAc)3
Ovaj enzim učestvuje u sintezi glikoproteina.
Reference[uredi | uredi kod]
- ↑ Harpaz, N. and Schachter, H. (1980). „Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β2-N-acetylglucosaminyltransferase I”. J. Biol. Chem. 255: 4894-4902. PMID 6445359.
- ↑ Tulsiani, D.R.P., Hubbard, S.C., Robbins, P.W. and Touster, O. (1982). „α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates”. J. Biol. Chem. 257: 3660-3668. PMID 7061502.
- ↑ Tulsiani, D.R.P., Opheim, D.J. and Touster, O. (1977). „Purification and characterization of α-D-mannosidase from rat liver golgi membranes”. J. Biol. Chem. 252: 3227-3233. PMID 863880.
- ↑ Athanasopoulos, V.I., Niranjan, K. and Rastall, R.A. (2005). „The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis”. Carbohydr. Res. 340: 609-617. PMID 15721331.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.