Makrofagna elastaza
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| Makrofagna elastaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.65 | ||||||||
| CAS broj | 2594837 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Makrofagna elastaza (EC 3.4.24.65, metaloelastaza, ljudska makrofagna metaloelastaza (HME)) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza rastvornog i nerastvornog elastina. Do specifičnog razlaganja takođe dolazi u Ala14-Leu- i -Tyr16-Leu- u B lancu insulina
Ovaj enzim se formira iz proenzima sa masom od 53 kDa.
Reference[uredi | uredi kod]
- ↑ Banda, M.J. and Werb, Z. (1981). „Mouse macrophage elastase. Purification and characterization as a metalloproteinase”. Biochem. J. 193: 589-605. PMID 7030312.
- ↑ Kettner, C., Shaw, E., White, R. and Janoff, A. (1981). „The specificity of macrophage elastase on the insulin B-chain”. Biochem. J. 195: 369-372. PMID 7032505.
- ↑ Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M. and Ley, T.J. (1992). „Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase”. J. Biol. Chem. 267: 4664-4671. PMID 1537850.
- ↑ Shapiro, S.D., Kobayashi, D.K. and Ley, T.J. (1993). „Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages”. J. Biol. Chem. 268: 23824-23829. PMID 8226919.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.