Makrocin O-metiltransferaza
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| Makrocin O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.101 | ||||||||
| CAS broj | 79468-52-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Makrocin O-metiltransferaza (EC 2.1.1.101, makrocinska metiltransferaza, S-adenozil-L-metionin-makrocinska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:makrocin 3'-O-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
3-hidroksi grupa 2-O-metil-6-dezoksi-D-aloznog ostatka u makrolidnom antibiotiku makrozinu deluje kao metil akceptor. Ovaj enzim takođe konvertuje laktenozin u desmikocin.
Reference[uredi | uredi kod]
- ↑ Bauer, N.J., Kreuzman, A.J., Dotzlaf, J.E. and Yeh, W.-K. (1988). „Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae”. J. Biol. Chem. 263: 15619-15625. PMID 3170601.
- ↑ Kreuzman, A.J., Turner, J.R. and Yeh, W.-K. (1988). „Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism”. J. Biol. Chem. 263: 15626-15633. PMID 3170602.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.