M7GpppN-iRNK hidrolaza
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| M7GpppN-iRNK hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.62 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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M7GpppN-iRNK hidrolaza (EC 3.6.1.62, Dcp2, NUDT16, D10 protein, D9 protein, D10 okrivajući enzim, otkrivajući enzim) je enzim sa sistematskim imenom m7GpppN-iRNK m7GDP fosfohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- :m7G5'ppp5'-iRNK + H2O m7GDP + 5'-fosfo-iRNK
Uklanjanje kape sa iRNK je kritičan korak pri razlaganju eukariotseke iRNK.
Reference[uredi | uredi kod]
- ↑ Xu, J., Yang, J.Y., Niu, Q.W. and Chua, N.H. (2006). „Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development”. Plant Cell 18: 3386-3398. PMID 17158604.
- ↑ Lu, G., Zhang, J., Li, Y., Li, Z., Zhang, N., Xu, X., Wang, T., Guan, Z., Gao, G.F. and Yan, J. (2011). „hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA”. Protein Cell 2: 64-73. PMID 21337011.
- ↑ van Dijk, E., Cougot, N., Meyer, S., Babajko, S., Wahle, E. and Seraphin, B. (2002). „Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures”. EMBO J. 21: 6915-6924. PMID 12486012.
- ↑ Parrish, S., Resch, W. and Moss, B. (2007). „Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression”. Proc. Natl. Acad. Sci. USA 104: 2139-2144. PMID 17283339.
- ↑ Souliere, M.F., Perreault, J.P. and Bisaillon, M. (2009). „Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism”. Biochem. J. 420: 27-35. PMID 19210265.
- ↑ Parrish, S. and Moss, B. (2007). „Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses”. J. Virol. 81: 12973-12978. PMID 17881455.
- ↑ Song, M.G., Li, Y. and Kiledjian, M. (2010). „Multiple mRNA decapping enzymes in mammalian cells”. Mol. Cell 40: 423-432. PMID 21070968.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.