Litoholat 6-beta-hidroksilaza
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| Litoholat 6-beta-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.94 | ||||||||
| CAS broj | 9075-83-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Litoholat 6-beta-hidroksilaza (EC 1.14.13.94, litoholatna 6beta-monooksigenaza, CYP3A10, 6beta-hidroksilaza, citohrom P450 3A10/lithocholic kiselina 6beta-hidroksilaza) je enzim sa sistematskim imenom litoholat,NADPH:kiseonik oksidoreduktaza (6beta-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- litoholat + NADPH + H+ + O2 6beta-hidroksilithoholat + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450). Ovaj enzim je 50-puta više izražen kod muških hrčaka.
Reference[uredi | uredi kod]
- ↑ Teixeira, J. and Gil, G. (1991). „Cloning, expression, and regulation of lithocholic acid 6β-hydroxylase”. J. Biol. Chem. 266: 21030-21036. PMID 1840595.
- ↑ Chang, T.K., Teixeira, J., Gil, G. and Waxman, D.J. The lithocholic acid 6beta-hydroxylase cytochrome P-450, CYP (1993). „3A10, is an active catalyst of steroid-hormone 6β-hydroxylation”. Biochem. J. 291: 429-433. PMID 8484723.
- ↑ Subramanian, A., Wang, J. and Gil, G. (1998). „STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6β-hydroxylase”. Nucleic Acids Res. 26: 2173-2178. PMID 9547277.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.