Linolenat 9R-lipoksigenaza
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| Linolenat 9R-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.61 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Linolenat 9R-lipoksigenaza (EC 1.13.11.61, NspLOX, (9R)-LOX, linoleatna 9R-dioksigenaza) je enzim sa sistematskim imenom alfa-linolenat:kiseonik (9R)-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alfa-linolenat + O2 (9R,10E,12Z,15Z)-9-hidroperoksioktadeka-10,12,15-trienoat
Kod cijanobakterija ovaj enzim učestvuje u biosintezi oksilipina. Enzim takođe konvertuje linoleat do (9R,10E,12Z)-9-hidroperoksioktadeka-10,12-dienoata.
Reference[uredi | uredi kod]
- ↑ Jerneren, F., Hoffmann, I. and Oliw, E.H. (2010). „Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus”. Arch. Biochem. Biophys. 495: 67-73. PMID 20043865.
- ↑ Andreou, A.Z., Vanko, M., Bezakova, L. and Feussner, I. (2008). „Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms”. Phytochemistry 69: 1832-1837. PMID 18439634.
- ↑ Lang, I., Gobel, C., Porzel, A., Heilmann, I. and Feussner, I. (2008). „A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120”. Biochem. J. 410: 347-357. PMID 18031288.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.