Linoleat 10R-lipoksigenaza
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| Linoleat 10R-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.62 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Linoleat 10R-lipoksigenaza (EC 1.13.11.62, 10R-DOX, (10R)-dioksigenaza, 10R-dioksigenaza) je enzim sa sistematskim imenom linoleat:kiseonik (10R)-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- linoleat + O2 (8E,10R,12Z)-10-hidroperoksi-8,12-oktadekadienoat
Ovaj enzim učestvuje u biosintezi oksilipina, koji utiče na sporulaciju, razviće i patogenost Aspergillus sp.
Reference[uredi | uredi kod]
- ↑ Garscha, U. and Oliw, E.H. (2009). „Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity”. J. Biol. Chem. 284: 13755-13765. PMID 19289462.
- ↑ Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta 1801: 503-507. PMID 20045744.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.