Lijaza fotoprodukta spora
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| Spore photoproduct lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.14 | ||||||||
| CAS broj | 37290-70-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lijaza fotoprodukta spora (EC 4.1.99.14, SAM, SP lijaza, SPL, SplB, SplG) je enzim koji popravlja posebnu vrstu oštećenja formiranih UV ozračenjem bakterijske DNK. Ovaj mehanizam popravke je jedan od razloga za otpornot pojedinih bakterijskih spora. Ovaj enzim je zavistan od radikala SAM. Putem serije reakcija radikala fotodimer, 3 5-timinil-5,6-dihidrotimin, se razlaže u dva funkcionalna prstena timina.[1][2]
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Reference[uredi | uredi kod]
- ↑ Susan C. Wang and Perry A. Frey (2007). „S-adenosylmethionine as an oxidant: the radical SAM superfamily”. Trends in Biochemical Sciences 32 (3): 101. DOI:10.1016/j.tibs.2007.01.002. PMID 17291766.Note that the SPL drawings are incorrect in this paper and the erratum
- ↑ Jeffrey M. Buis, Jennifer Cheek, Efthalia Kalliri, and Joan B. Broderick (2006). „Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily”. Journal of Biological Chemistry 281 (36): 25994–26003. DOI:10.1074/jbc.M603931200. PMID 16829680.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.