Leukotrienska C4 hidrolaza

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Leukotrienska C4 hidrolaza
Identifikatori
EC broj 3.4.19.14
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Leukotrienska C4 hidrolaza (EC 3.4.19.14, gama-glutamilna leukotrienaza, GGT5) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

leukotrien C4 + H2O leukotrien D4 + L-glutamat

Ovaj mišji enzim je specifičan za leukotrien C4.

Reference[uredi - уреди | uredi izvor]

  1. Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N. and Lieberman, M.W. (1997). "Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice". J. Biol. Chem. 272: 12305–12310. PMID 9139674. 
  2. Shi, Z.Z., Han, B., Habib, G.M., Matzuk, M.M. and Lieberman, M.W. (2001). "Disruption of γ-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response". Mol. Cell Biol. 21: 5389–5395. PMID 11463821. 
  3. Han, B., Luo, G., Shi, Z.Z., Barrios, R., Atwood, D., Liu, W., Habib, G.M., Sifers, R.N., Corry, D.B. and Lieberman, M.W. (2002). "γ-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo". Am J Pathol 161: 481–490. PMID 12163373. 
  4. Wickham, S., West, M.B., Cook, P.F. and Hanigan, M.H. (2011). "Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes". Anal. Biochem. 414: 208–214. PMID 21447318. 

Literatura[uredi - уреди | uredi izvor]

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