Leukotrien-A4 hidrolaza

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Leukotrien-A4 hidrolaza
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Identifikatori
EC broj 3.3.2.6
CAS broj 90119-07-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Leukotrien-A4 hidrolaza (EC 3.3.2.6, LTA4 hidrolaza, LTA4H, leukotrienska A4 hidrolaza) je enzim sa sistematskim imenom (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoksiikosa-7,9,11,14-tetraenoatna hidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

leukotrien A4 + H2O leukotrien B4

Ova bifunkcionalna cinkova metaloproteaza deluje kao epoksidna hidrolaza i aminopeptidaza.

Reference[uredi - уреди | uredi izvor]

  1. Evans, J.F., Dupuis, P. and Ford-Hutchinson, A.W. (1985). "Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils". Biochim. Biophys. Acta 840: 43–50. PMID 3995081. 
  2. Minami, M., Ohno, S., Kawasaki, H., Rådmark, O., Samuelsson, B., Jörnvall, H., Shimizu, T., Seyama, Y. and Suzuki, K. (1987). "Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase - complete primary structure of an enzyme involved in eicosanoid synthesis". J. Biol. Chem. 262: 13873–13876. PMID 3654641. 
  3. Haeggström, J., Meijer, J. and Rådmark, O. (1986). "Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. Chem. 261: 6332–6337. PMID 3009453. 
  4. Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44: 1–51. PMID 15748653. 
  5. Fretland, A.J. and Omiecinski, C.J. (2000). "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129: 41–59. PMID 11154734. 
  6. Orning, L., Gierse, J.K. and Fitzpatrick, F.A. (1994). "The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity". J. Biol. Chem. 269: 11269–11267. PMID 8157657. 
  7. Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). "Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers". J. Biol. Chem. 262: 10200–10205. PMID 3038871. 

Literatura[uredi - уреди | uredi izvor]

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