L-lizinska ciklodeaminaza
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| L-lizinska ciklodeaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.28 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
L-lizinska ciklodeaminaza (EC 4.3.1.28, rapL (gen), fkbL (gen), tubZ (gen), visC (gen)) je enzim sa sistematskim imenom L-lizin amonijak-lijaza (ciklizacija, formira amonijak).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-lizin L-pipekolat + NH3
Za dejstvo ovog enzma je neophodan NAD+.
Reference[uredi | uredi kod]
- ↑ Khaw, L.E., Bohm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (1998). „Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase”. J. Bacteriol. 180: 809-814. PMID 9473033.
- ↑ Gatto, G.J., Jr., Boyne, M.T., 2nd, Kelleher, N.L. and Walsh, C.T. (2006). „Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster”. J. Am. Chem. Soc. 128: 3838-3847. PMID 16536560.
- ↑ Tsotsou, G.E. and Barbirato, F. (2007). „Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase”. Biochimie 89: 591-604. PMID 17291665.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.