Kvorum-sensing N-acil-homoserinska laktonaza

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Kvorum-sensing N-acil-homoserinska laktonaza
Identifikatori
EC broj 3.1.1.81
CAS broj 389867-43-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kvorum-sensing N-acil-homoserinska laktonaza (EC 3.1.1.81, acil homoserin degradirajući enzim, acil-homoserin laktonska acilaza, AHL laktonaza, AHL-degradirajući enzim, AHL-inaktivirajući enzim, AHLaza, AhlD, AhlK, AiiA, AiiA laktonaza, AiiA-sličan protein, AiiB, AiiC, AttM, delaktonaza, laktonazi sličan enzim, N-acil homoserin laktonaza, N-acil homoserin laktonska hidrolaza, N-acil-homoserin laktonska laktonaza, N-acil-L-homoserin laktonska hidrolaza, kvorum-sensing laktonaza, kvorum-sensing N-acil homoserin laktonska hidrolaza) je enzim sa sistematskim imenom N-acil-L-homoserin-lakton laktonohidrolaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju

N-acil-L-homoserin lakton + H2O N-acil-L-homoserin

Acil-homoserinske laktone (AHL) formiraju gram negativne bakterije i obično ih koriste kao signalni molekul za međusobnu komunikaciju u procesu kvorum-sensinga. AHL se vezuje za transkripcione faktore i na taj način utiče na ekspresiju gena. Ovim vidom komunikacije bakterije regulišu brojne biološke funkcije, uključujući i sekreciju faktora virulencije.

Reference[uredi - уреди | uredi izvor]

  1. Thomas, P.W., Stone, E.M., Costello, A.L., Tierney, D.L. and Fast, W. (2005). "The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein". Biochemistry 44: 7559–7569. PMID 15895999. 
  2. Dong, Y.H., Gusti, A.R., Zhang, Q., Xu, J.L. and Zhang, L.H. (2002). "Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species". Appl. Environ. Microbiol. 68: 1754–1759. PMID 11916693. 
  3. Wang, L.H., Weng, L.X., Dong, Y.H. and Zhang, L.H. (2004). "Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase (AHL-lactonase)". J. Biol. Chem. 279: 13645–13651. PMID 14734559. 
  4. Dong, Y.H., Xu, J.L., Li, X.Z. and Zhang, L.H. (2000). "AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora". Proc. Natl. Acad. Sci. USA 97: 3526–3531. PMID 10716724. 
  5. Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F. and Zhang, L.H. (2001). "Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase". Nature 411: 813–817. PMID 11459062. 
  6. Lee, S.J., Park, S.Y., Lee, J.J., Yum, D.Y., Koo, B.T. and Lee, J.K. (2002). "Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis". Appl. Environ. Microbiol. 68: 3919–3924. PMID 12147491. 
  7. Park, S.Y., Lee, S.J., Oh, T.K., Oh, J.W., Koo, B.T., Yum, D.Y. and Lee, J.K. (2003). "AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria". Microbiology 149: 1541–1550. PMID 12777494. 
  8. Ulrich, R.L. (2004). "Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis". Appl. Environ. Microbiol. 70: 6173–6180. PMID 15466564. 
  9. Kim, M.H., Choi, W.C., Kang, H.O., Lee, J.S., Kang, B.S., Kim, K.J., Derewenda, Z.S., Oh, T.K., Lee, C.H. and Lee, J.K. (2005). "The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase". Proc. Natl. Acad. Sci. USA 102: 17606–17611. PMID 16314577. 
  10. Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W. and Ringe, D. (2005). "Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis". Proc. Natl. Acad. Sci. USA 102: 11882–11887. PMID 16087890. 
  11. Yang, F., Wang, L.H., Wang, J., Dong, Y.H., Hu, J.Y. and Zhang, L.H. (2005). "Quorum quenching enzyme activity is widely conserved in the sera of mammalian species". FEBS Lett. 579: 3713–3717. PMID 15963993. 

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