Kobalt-prekorin-7 (C15)-metiltransferaza (dekarboksilacija)
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| Kobalt-prekorin-7 (C15)-metiltransferaza (dekarboksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.196 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kobalt-prekorin-7 (C15)-metiltransferaza (dekarboksilacija) (EC 2.1.1.196, CbiT) je enzim sa sistematskim imenom S-adenozil-L-metionin:prekorin-7 C15-metiltransferaza (C-12-dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- kobalt-prekorin-7 + S-adenozil-L-metionin kobalt-prekorin-8x + S-adenozil-L-homocistein + CO2
Ovaj enzim katalizuje metilaciju u poziciji C-15 i dekarboksilaciju u poziciji C-12 acetatnog bočnog lanca kobalt-prekorina-7. To je korak u anaerobnoj biosintezi adenozilkobalamina.
Reference[uredi | uredi kod]
- ↑ Keller, J.P., Smith, P.M., Benach, J., Christendat, D., deTitta, G.T. and Hunt, J.F. (2002). „The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase”. Structure 10: 1475-1487. PMID 12429089.
- ↑ Santander, P.J., Kajiwara, Y., Williams, H.J. and Scott, A.I. (2006). „Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway”. Bioorg. Med. Chem. 14: 724-731. PMID 16198574.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.