KoB-KoM heterodisulfid reduktaza

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KoB-KoM heterodisulfid reduktaza
Identifikatori
EC broj 1.8.98.1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

KoB-KoM heterodisulfid reduktaza (EC 1.8.98.1, heterodisulfidna reduktaza, rastvorna heterodisulfidna reduktaza) je enzim sa sistematskim imenom koenzim B:koenzim M:metanofenazin oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

koenzim B + koenzim M + metanofenazin N7-[(2-sulfoetil)ditio]heptanoilO3-fosfo-L-treonin + dihidrometanofenazin

Ovaj enzim je prisutan kod metanogenih arheja, posebno kod metanosarcina vrsta. On regeneriše koenzim M i koenzim B nakon dejstva enzima EC 2.8.4.1, koenzim-B sulfoetiltiotransferaze.

Reference[uredi | uredi kod]

  1. Hedderich, R., Berkessel, A. and Thauer, R.K. (1990). „Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg)”. Eur. J. Biochem. 193: 255-261. PMID 2121478. 
  2. Abken, H.J., Tietze, M., Brodersen, J., Bäumer, S., Beifuss, U. and Deppenmeier, U. (1998). „Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei gol”. J. Bacteriol. 180: 2027-2032. PMID 9555882. 
  3. Simianu, M., Murakami, E., Brewer, J.M. and Ragsdale, S.W. (1998). „Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila”. Biochemistry 37: 10027-10039. PMID 9665708. 
  4. Murakami, E., Deppenmeier, U. and Ragsdale, S.W. (2001). „Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila”. J. Biol. Chem. 276: 2432-2439. PMID 11034998. 

Literatura[uredi | uredi kod]

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