Mikrobna kolagenaza
Mikrobna kolagenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.3 | ||||||||
CAS broj | 2593923 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Mikrobna kolagenaza (EC 3.4.24.3, Clostridium histolyticum kolagenaza, klostridiopeptidaza A, kolagenaza A, kolagenaza I, Achromobacter iophagus kolagenaza, kolagenaza, aspergilopeptidaza C, nukleolizin, azokolaza, metalokolagenaza, soikolagestin, Clostridium histolyticum proteinaza A, klostridiopeptidaza II, MMP-8, klostridiopeptidaza I, kolagenska peptidaza, kolagenska proteaza, kolagenaza MMP-1, metaloproteinaza-1, kolaza, matriks metaloproteinaza-1, MMP-1, matriks metaloproteinaza-8, matriks metaloproteinaza-18) je enzim.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Varenje prirodnog kolagena u regionu trostrukog heliksa na -Gly vezama. Na sintetičkim peptidima preferentno deluje na Gly u P3 i P1', Pro i Ala u P2 i P2', i hidroksiprolin, Ala ili Arg u P3'
Ovaj enzim je jedan od šest metaloendopeptidaza koji deluju na prirodni kolagen i koji su prisutni u medijumu bakterije Clostridium histolyticum.
Reference[uredi | uredi kod]
- ↑ Hanada, K., Mizutani, T., Yamagishi, M., Tsuji, H., Misaki, T. Sawada, J. (1973). „The isolation of collagenase and its enzymological and physico-chemical properties”. Agric. Biol. Chem. 37: 1771-1781.
- ↑ Merkel, J.R. and Dreisbach, J.H. (1978). „Purification and characterization of a marine bacterial collagenase”. Biochemistry 17: 2857-2863. PMID 210785.
- ↑ Heindl, M.-C., Fermandjian, S. and Keil, B. (1980). „Circular dichroism comparative studies of two bacterial collagenases and thermolysin”. Biochim. Biophys. Acta 624: 51-59. PMID 6250633.
- ↑ Labadie, J. and Montel, M..-C. (1982). „Purification et étude de quelques propriétés d’une collagénase produite par Empedobacter collagenolyticum”. Biochimie 64: 49-54. PMID 6530724.
- ↑ Bond, M.D and Van Wart, H.D. (1984). „Characterization of the individual collagenases from Clostridium histolyticum”. Biochemistry 23: 3085-3091. PMID 6087888.
- ↑ Bond, M.D. and Van Wart, H.D. (1984). „Relationship between the individual collagenases of Clostridium histolyticum: evidience for evolution by gene duplication”. Biochemistry 23: 3092-3099. PMID 6087889.
- ↑ Van Wart, H.D. and Steinbrink, D.R. (1985). „Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum”. Biochemistry 24: 6520-6526. PMID 3002445.
- ↑ Tong, N.T., Tsugita, A. and Keil-Dlouha, V. (1986). „Purification and characterization of two high-molecular-mass forms of Achromobacter collagenase”. Biochim. Biophys. Acta 874: 296-304.
- ↑ Endo, A., Murakawa, S., Shimizu, H. and Shiraishi, Y. (1987). „Purification and properties of collagenase from a Streptomyces species”. J. Biochem. (Tokyo) 102: 163-170. PMID 2822678.
- ↑ Makinen, K.K. and Makinen, P.-L. (1987). „Purification and properties of an extracellular collagenolytic protease produced by the human oral bacterium Bacillus cereus (strain Soc 67)”. J. Biol. Chem. 262: 12488-12495. PMID 3040751.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.