Kjuin tRNK-riboziltransferaza
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| Kjuin tRNK-riboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.29 | ||||||||
| CAS broj | 72162-89-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kjuin tRNK-riboziltransferaza (EC 2.4.2.29, enzim umetanja kjuina, tRNK transglikozilaza, Q-insertaza, kjuin34 transfer ribonukleatna riboziltransferaza, transfer ribonukleatna glikoziltransferaza, tRNK kjuin34 transglikosidaza, kjuinska tRNK-riboziltransferaza, TGT, (tRNK)-kjuin34:kjuin tRNK-D-riboziltransferaza, transfer ribonukleinska kiselina kjuin34 transglikozilaza) je enzim sa sistematskim imenom tRNK-guanozin34:kjuin tRNK-D-riboziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) guanin34 u tRNK + kveuin kveuin34 u tRNK + guanin
- (2) guanin34 u tRNK + 7-aminometil-7-karbaguanin 7-aminometil-7-karbaguanin34 u tRNK + guanin
Pojedine prokariotske i eukariotske tRNK sadrže modifikovanu bazu kjuin u poziciji 34.
Reference[uredi | uredi kod]
- ↑ Howes, N.K. and Farkas, W.R. (1978). „Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA”. J. Biol. Chem. 253: 9082-9087. PMID 721832.
- ↑ Okada, N., Noguchi, S., Kasai, H., Shindo-Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1979). „Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction”. J. Biol. Chem. 254: 3067-3073. PMID 372186.
- ↑ Shindo-Okada, N., Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1980). „Transfer ribonucleic acid guanine transglycosylase isolated from rat liver”. Biochemistry 19: 395-400. PMID 6986171.
- ↑ Todorov, K.A. and Garcia, G.A. (2006). „Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity”. Biochemistry 45: 617-625. PMID 16401090.
- ↑ Boland, C., Hayes, P., Santa-Maria, I., Nishimura, S. and Kelly, V.P. (2009). „Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase”. J. Biol. Chem. 284: 18218-18227. PMID 19414587.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.